Innate within Cypress, California, to Bill & Loretta Stamos, John has 2 sisters, Janeen and Alaina. He has appeared inside the total of film flick, commercials and television sitcoms since 1982. He inaugurate his acting career by owning the role inside General Hospital, also with starred inside an airless Coca-Cola advertisement.

Stamos is better known for his role when a character of Jesse Katsopolis in Full House from 1987-1995, an "Elvis Presley -obsessed" "hot" Great hair" rocker and motorcycle aficionado. Jesse moved in with his brother-in-law, Danny Tanner, to help him raise his kids D.J., Stephanie and Michelle after the death of Danny's wife, Pamela. Jesse has his own rock band called Jesse and the Rippers. His attitude could be described as cool and carefree. Jesse has great hair which he pampers a great deal. Later, he marries Rebecca Donaldson, Danny's co-host on Wake Up San Francisco. The couple has twins, Nicky and Alex.

John married supermodel Rebecca Romijn-Stamos in 1998. This was the first marriage for them both, and they had no children. The couple separated in 2004 and officially divorced in 2005.

On the musical front, John has toured with The Beach Boys as a drummer on and off for 15 years.

In November 2000, Stamos was the winning bidder in the eBay auction of the Disneyland sign, with fourteen-foot-tall letters, which had stood at the entrance to the park for the past decade. He paid $30,700 for it.

He did 10-10-987 commercials in 2004.

Stamos currently stars in the TV series Jake in Progress on ABC.

He also will play a roll on the hit NBC series ER